Climate change poses serious threats to agriculture, impacting food security and livelihoods globally. Nepal, one of the most vulnerable countries, faces challenges such as food insecurity in multiple districts, changing rainfall patterns, temperature variations, and the risk of glacial lake outbursts. To address these issues, Climate-Smart Agriculture (CSA) offers an integrated approach that combines eco-friendly practices like no-tillage, intercropping, integrated pest management, rainwater harvesting, and the use of ICTs to enhance productivity with minimal environmental impact. Climate-Smart Villages (CSVs) in Nepal serve as models for implementing these practices, fostering resilience among smallholder farmers and marginalized groups. This paper reviews the impacts of climate change on agriculture, discusses CSA practices, and examines ongoing programs and policies aimed at enhancing food security and adapting to changing environmental conditions in Nepal.